ea0073aep405 | Environmental Endocrinology | ECE2021
Lee Dongtao
, Macleod Kenneth
, Higgins Larry
, McBrinn Rachel
, Dickinson Robin
, McGinnis Claudia
Thyroid hormones are important regulators of metabolism and development. Iodothyronine selenodeiodinases can both activate and inactivate thyroid hormones (Bianco et al. 2002) thus in vitro assays to quantify deiodinase inhibition are considered to be a valuable tool for studying effects on thyroid hormone metabolism by potential endocrine disruptors. The prohormone thyroxine (T4) is converted to 3, 5, 3-triiodothyronine (T3) by outer-ring deiodination,...